二、治疗依从性面临较高脱落风险，约25%的患儿难以坚持规范的GnRHa治疗[4]。

参考文献（滑动查看） [1]Ribot, T. (1897). The Psychology of the Emotions. London: Walter Scott Publishing Co. [2]Cheng, C., Herr, K., Jeon, H. J., Kato, T., Ng, C. H., Yang, Y. K., & Zhang, L. (2024). A Delphi consensus on clinical features, diagnosis and treatment of major depressive disorder patients with anhedonia amongst psychiatrists in the Asia-Pacific. Frontiers in psychiatry, 15, 1338063. https://doi.org/10.3389/fpsyt.2024.1338063 [3]Herr, K., Berk, M., Huang, W. L., Kato, T., Lee, J. G., Ng, C. G., Wang, Z., Webb, T. D., Kasahara-Kiritani, M., & Vandervoort, L. P. (2024). Anhedonia in major depressive disorder: Prevalence and treatment expectations and satisfaction with treatment goals among patients and physicians in Asia-Pacific. Neuropsychiatric Disease and Treatment, 20, 2177–2191. https://doi.org/10.2147/NDT.S487747 [4]Kasahara-Kiritani, M., Kato, T., Wakamatsu, A., Webb, T., Herr, K., Vandervoort, L., & Li, N. (2025). Understanding anhedonia in major depressive disorder in Japan: Epidemiology and unmet needs from patients' and physicians' perspectives. BMC Psychiatry, 25(1), 631. https://doi.org/10.1186/s12888-025-07089-4 [5]Lee, B., Kim, Y., Eum, H., Koo, J. S., Herr, K., Vandervoort, L., … & Lee, J. G. (2025). Prevalence and burden of anhedonia among patients with major depressive disorder in South Korea: A cross-sectional, observational study. PLOS ONE, 20(10), e0334525. https://doi.org/10.1371/journal.pone.0334525 [6]Treadway, M. T., & Zald, D. H. (2011). Reconsidering anhedonia in depression: Lessons from translational neuroscience. Neuroscience & Biobehavioral Reviews, 35(3), 537–555. [7]Gandhi, A., Mote, J., & Fulford, D. (2022). A transdiagnostic meta-analysis of physical and social anhedonia in major depressive disorder and schizophrenia spectrum disorders. Psychiatry Research, 309, 114379. [8]Gandhi, Mote & Fulford. A transdiagnostic meta-analysis of physical and social anhedonia in MDD and SSD (Psychiatry Research, 2022) [9]Schultz, W., Dayan, P., & Montague, P. R. (1997). A neural substrate of prediction and reward. Science, 275(5306), 1593–1599. [10]Beltrán, J., Li, M., Jacob, Y., Butler, G., Mehta, M., Murrough, J. W., Radulescu, A., & Morris, L. S. (2025). VTA network dominance in depression confers distinct psychopathological states through blunted neural tracking of reward prediction errors. Research square, rs.3.rs-7166201. https://doi.org/10.21203/rs.3.rs-7166201/v1 [11]Müller-Pinzler, L., Czekalla, N., Stolz, D. S., Mayer, A. V., Paulus, F. M., & Krach, S. (2024). Neurocomputational mechanisms underlying maladaptive self-belief formation in depression. bioRxiv. [12]Fan, Z., Chang, J., Liang, Y., Zhu, H., Zhang, C., Zheng, D., Wang, J., Xu, Y., Li, Q.-J., & Hu, H. (2023). Neural mechanism underlying depressive-like state associated with social status loss. Cell, 186(3), 560–576.e17. https://doi.org/10.1016/j.cell.2022.12.033 [13]利伯曼, D. Z., & 朗, M. E. (2021). 贪婪的多巴胺. 中信出版集团. [14]Bunzeck, N., & Düzel, E. (2006). Absolute coding of stimulus novelty in the human substantia nigra/VTA. Neuron, 51(3), 369–379. [15]Amabile, T., & Kramer, S. (2011). The progress principle: Using small wins to ignite joy, engagement, and creativity at work. Harvard Business Review Press. [16]Ryan, R. M., & Deci, E. L. (2000). Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. American Psychologist, 55(1), 68–78. https://doi.org/10.1037/0003-066X.55.1.68 对生活失去热情、长期感受不到快乐，或许是身心向你发出的求助信号。